Natural History of the Nephrotic Syndrome in Glomerulonephritis

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Abstract
It is not known whether the histologic renal changes in the nephrotic syndrome represent sequelae of classic acute glomerulonephritis or whether the nephrotic and non-nephrotic types of glomerulonephritis are different diseases. A tentative conclusion is reached, based on correlation of histologic and clinical observations in 22 cases, that the condition as defined herein is not a sequela of classic acute glomerulonephritis but a separate disease. The probable sequence of structural glomerular changes is described.