The Direct Effect of Oral Hypoglycaemic Agents on Glucose Metabolism by Adipose Tissue

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Abstract
The direct effect of tolbutamide, chlorpropamide and phenformin on glucose metabolism by adipose tissue has been studied in the rat epididymal fat pad. Phenformin at concentrations of 1 to 100 µgm/ml caused a progressive doserelated decrease in basal and insulin stimulated glucose oxidation and incorporation into lipid. These effects could not be accounted for by diminished glucose uptake since phenformin at 100 µgm/ml increased basal glucose uptake and did not interfere with the stimulating effect of insulin on this parameter. Tolbutamide and chlorpropamide at 1000 µgm/ml increased glucose oxidation and incorporation into lipid but at 50 and 250 µgm/ml were without effect. These findings may be of significance in relation to the weight changes seen in diabetic patients treated with these drugs.

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