Temporary Inhibition of Antibody-Dependent, Cell-Mediated Cytotoxicity by Pretreatment of Human Attacking Cells with Ammonium Chloride
Open Access
- 1 April 1976
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 116 (4) , 1170-1172
- https://doi.org/10.4049/jimmunol.116.4.1170
Abstract
Treatment of lymphoid cell preparations with ammonium chloride buffers to remove contaminating erythroid cells markedly reduced the ability of these cells to function as attacking cells in antibody dependent cell mediated cytotoxicity tests (ADCC). The lymphoid cells, however, retained their ability to adhere to antibody-coated target cells Recovery of function 20 hr after exposure to ammonium chloride suggests a metabolic rather than receptor effect of these salts on the ADCC function of lymphocytes.This publication has 1 reference indexed in Scilit: