Transition Metal Catalyzed [2+2+2] Cycloaddition and Application in Organic Synthesis
Top Cited Papers
- 1 November 2005
- journal article
- review article
- Published by Wiley in European Journal of Organic Chemistry
- Vol. 2005 (22) , 4741-4767
- https://doi.org/10.1002/ejoc.200500411
Abstract
The [2+2+2] cycloaddition strategy is complementary to the well known Diels–Alder reaction for the generation of polycyclic compounds. This [2+2+2] approach is atom‐economical and, with the availability of new catalysts to effect the [2+2+2] cycloaddition reaction, synthesis of a wide variety of highly functionalized polycycles is possible. This review deals with some recent advances relating to [2+2+2] cycloaddition reactions involving the syntheses both of polycycles and of heterocycles. More specifically, syntheses of various biologically active molecules, unusual amino acids, and theoretically interesting molecules are described. An attempt has also been made to give an overview of recent advances in the achievement of chemo‐, regio‐, and stereoselectivity in cyclotrimerization reactions. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)Keywords
This publication has 149 references indexed in Scilit:
- Synthesis and Properties of Hexakis(6-octyl-2-azulenyl)benzene as a Multielectron Redox System with Liquid Crystalline BehaviorThe Journal of Organic Chemistry, 2005
- Transition Metal-Mediated Intramolecular [2+2+2] Cycloisomerizations of Cyclic Triynes and EnediynesThe Journal of Organic Chemistry, 2005
- Cocyclotrimerization of 6-Alkynylpurines with α,ω-Diynes as a Novel Approach to Biologically Active 6-ArylpurinesThe Journal of Organic Chemistry, 2004
- Ruthenium(II)-Catalyzed Selective Intramolecular [2 + 2 + 2] Alkyne CyclotrimerizationsJournal of the American Chemical Society, 2003
- Mechanism for the Cyclotrimerization of Alkynes and Related Reactions Catalyzed by CpRuClJournal of the American Chemical Society, 2003
- Highly Regioselective Alkyne Cyclotrimerization Catalyzed by Titanium Complexes Supported by Proximally Bridged p-tert-Butylcalix[4]arene LigandsJournal of the American Chemical Society, 1999
- Theoretical Study of the Acetylene Trimerization with CpCoJournal of the American Chemical Society, 1999
- The First Metallacyclopentadiene(Alkyne) Complexes and Their Discrete Isomerization to η4-Bound Arenes: The Missing Link in the Prevalent Mechanism of Transition Metal Catalyzed Alkyne Cyclotrimerizations, as Exemplified by CyclopentadienylcobaltJournal of the American Chemical Society, 1998
- Disilane-Catalyzed Cyclotrimerization of AcetylenesJournal of the American Chemical Society, 1998
- Transition-metal-catalyzed acetylene cyclizations in organic synthesisAccounts of Chemical Research, 1977