Antibacterial Activity Evaluation of Microcin J25 against Diarrheagenic Escherichia coli

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Abstract
The inhibitory activities of known microcins were evaluated against some diarrheagenic Escherichia coli strains. Some antibacterial properties of microcin J25, the most active one, were studied. A rapid two-step purification was performed. The MIC and the minimum bactericidal concentration of J25 against E. coli O157:H7 were 1 and 100 μg ml −1 , respectively. A 10 4 -CFU ml −1 contamination by this strain was destroyed in milk and meat extract by 6.25 μg of J25 ml −1 and in half-diluted egg yolk by 50 μg of J25 ml −1 .