Anti-Inflammatory Activity of Piperonyl-4-Acrylic Isobutyl Amide, an Extractive from Zanthoxylum zanthoxyloides

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Abstract
The anti-inflammatory activity of piperonyl-4-acrylicisobutyl-amide (fagaramide) has been studied. Fagaramide was effective against carrageenan paw oedema in rats and was approximately twenty times less potent than indomethacin, a non-steroidal anti-inflammatory agent. Fagaramide was effective against the prostaglandin phase of an acute experimental inflammatory reaction. It dose-dependently inhibited prostaglandin synthesis in vitro but had no effect on PGE1 - induced potentiation of carrageenan oedema in indomethacin treated rats. It is thus suggested that at least part of the anti-inflammatory activity of fagaramide is mediated via inhibition of prostaglandin synthesis.