On the probability of implanted disulfiram's causing a reaction to ethanol.
- 1 January 1978
- journal article
- research article
- Published by Alcohol Research Documentation, Inc. in Journal of Studies on Alcohol
- Vol. 39 (1) , 183-186
- https://doi.org/10.15288/jsa.1978.39.183
Abstract
The amount of liver aldehyde dehydrogenase [AD] inactivated daily by implanted disulfiram was estimated using available information on the level of the enzyme in the human liver and its speed of regeneration, the fate of disulfiram implant in the human organism, and the amount of disulfiram bound to protein in the liver and plasma of mice. The estimate was based on the assumption that all protein-bound disulfiram is bound to AD and that the stoichiometry of this binding is 1:1. Implanted disulfiram does not produce disulfiram-ethanol reaction symptoms.This publication has 5 references indexed in Scilit:
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