Anti-HSP70 Autoantibody Formation by B-1 Cells inToxoplasma gondii-Infected Mice
Open Access
- 1 September 2000
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 68 (9) , 4893-4899
- https://doi.org/10.1128/iai.68.9.4893-4899.2000
Abstract
Formation of anti-Toxoplasma gondii HSP70 (TgHSP70) antibody cross-reactive to mouse HSP70 (mHSP70) was observed in the sera of BALB/c (a resistant strain) and C57BL/6 (B6; a susceptible strain) mice after peroral infection with T. gondii cysts of the Fukaya strain. The levels of anti-mHSP70 immunoglobulin G (IgG) autoantibody production in B6 mice were higher than those in BALB/c mice. The isotype and subclass of IgG of anti-TgHSP70 monoclonal antibodies cross-reactive to mHSP70 were μ and γ3. Anti-mHSP70 autoantibody in T. gondii-infected BALB/c and B6 mice was shown to be produced by the CD5+subset of B cells (B-1a cells) but not by conventional B cells (B-2 cells). The epitopes recognized by anti-mHSP70 autoantibody were located primarily in the C-terminal fragment of mHSP70.Keywords
This publication has 60 references indexed in Scilit:
- Modulation of macrophage heat shock proteins (HSPs) expression in response to intracellular infection by virulent and avirulent strains of Leishmania donovaniIUBMB Life, 1997
- Antibodies Against Stress Proteins in Sera of Patients with Dilated CardiomyopathyJournal of Molecular and Cellular Cardiology, 1997
- Signal Transducer and Activator of Transcription-3 (STAT3) Is Constitutively Activated in Normal, Self-renewing B-1 Cells but Only Inducibly Expressed in Conventional B LymphocytesThe Journal of Experimental Medicine, 1997
- Serological reactivity to heat shock protein 70 in patients with hydatid diseaseParasite Immunology, 1997
- Involvement of B-1 cells in mucosal immunity and autoimmunityImmunology Today, 1995
- Increased CD4+T cell-dependent anti-erythrocyte antibody levels following the onset of parasite egg production in Schistosoma mansoni infected miceParasite Immunology, 1994
- Oral administration of lipopolysaccharides activates B-1 cells in the peritoneal cavity and lamina propria of the gut and induces autoimmune symptoms in an autoantibody transgenic mouse.The Journal of Experimental Medicine, 1994
- Identification of the low affinity receptor for immunoglobulin E on mouse mast cells and macrophages as Fc gamma RII and Fc gamma RIII.The Journal of Experimental Medicine, 1992
- Heat shock proteins in host-parasite interactionsImmunology Today, 1991
- Peritoneal Ly‐1 B cells: Genetic control, autoantibody production, increased lambda light chain expressionEuropean Journal of Immunology, 1986