The production of pig tissue sulphadimidine reference material
- 1 February 1996
- journal article
- research article
- Published by Taylor & Francis in Food Additives & Contaminants
- Vol. 13 (2) , 211-219
- https://doi.org/10.1080/02652039609374399
Abstract
The production of stable homogeneous reference materials containing the antimicrobial agent sulphadimidine in pig tissue is described. These were commissioned by the Community Bureau of Reference (BCR), established by the Commission of the European Communities, to promote improvements in analytical accuracy and to ensure uniformity of results determined by member states. Sulphadimidine‐containing tissue powders (400 vials each of muscle, liver and kidney) were prepared by orally dosing pigs with drug, producing lyophilized tissue powders and blending these with negative tissues from unmedicated animals to achieve target concentrations. Details of the production process, the stabilizing procedure developed and the analytical assessments of homogeneity and stability are given.Keywords
This publication has 6 references indexed in Scilit:
- Effects of short term exposure of unmedicated pigs to sulphadimidine contaminated housingPublished by Wiley ,1994
- Determination of sulphadimidine in animal feedstuffs by an enzyme‐linked immunoassayFood Additives & Contaminants: Part A, 1990
- Multiresidue method for the determination of sulfonamides in pork tissueJournal of Agricultural and Food Chemistry, 1990
- The BCR programme and measurements for food and agricultureAnalytical and Bioanalytical Chemistry, 1990
- Medicated feed: problems and solutionsPublished by Springer Nature ,1983
- Sulfamethazine residue in calf tissuesJournal of Agricultural and Food Chemistry, 1977