Analysis of pancreas tissue in a child positive for islet cell antibodies
- 12 August 2008
- journal article
- case report
- Published by Springer Nature in Diabetologia
- Vol. 51 (10) , 1796-1802
- https://doi.org/10.1007/s00125-008-1107-8
Abstract
Type 1 diabetes is caused by an immune-mediated process, reflected by the appearance of autoantibodies against pancreatic islets in the peripheral circulation. Detection of multiple autoantibodies predicts the development of diabetes, while positivity for a single autoantibody is a poor prognostic marker. The present study assesses whether positivity for a single autoantibody correlates with pathological changes in the pancreas.Keywords
This publication has 31 references indexed in Scilit:
- β-Cell Replication Is the Primary Mechanism Subserving the Postnatal Expansion of β-Cell Mass in HumansDiabetes, 2008
- Detection of enteroviruses in the intestine of type 1 diabetic patientsClinical and Experimental Immunology, 2007
- Screening for Insulitis in Adult Autoantibody-Positive Organ DonorsDiabetes, 2007
- Coxsackie B4 virus infection of β cells and natural killer cell insulitis in recent-onset type 1 diabetic patientsProceedings of the National Academy of Sciences, 2007
- Natural course of preclinical type 1 diabetes in siblings of affected childrenActa Paediatrica, 2003
- Enterovirus infections and type 1 diabetesAnnals of Medicine, 2002
- Coxsackie and adenovirus receptor (CAR)-dependent and major histocompatibility complex (MHC) class I-independent uptake of recombinant adenoviruses into human tumour cellsGene Therapy, 1999
- Persistent Infection of Human Vascular Endothelial Cells by Group B CoxsackievirusesThe Journal of Infectious Diseases, 1997
- Virus-Induced Diabetes MellitusNew England Journal of Medicine, 1979
- ISLET-CELL ANTIBODIES IN DIABETES MELLITUS WITH AUTOIMMUNE POLYENDOCRINE DEFICIENCIESThe Lancet, 1974