ROC Curve Analysis Of Super High Resolution Video For Histopathology

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Abstract
The receiver operator characteristic (ROC) curve is used to assess the ability of a diagnostic test to distinguish between two discreet states, such as tumor present or tumor absent in a histopathologic section. We have used ROC methodology to assess the ability of pathologists to diagnose frozen section biopsies of breast tissue as benign or malignant, using both a conventional light microscope and a high resolution camera/monitor system. 115 consecutive frozen section breast biopsies were reviewed using each of the above modalities. Results yielded identical ROC curves for the conventional light microscope and high resolution camera/monitor system. Furthermore, the percentage of cases in which pathologists rendered an "equivocal" diagnosis was the same with both modalities.

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