Unusual Reaction to Penicillin in Oil and Wax

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Abstract
AS new forms and combinations of penicillin have been developed, the reported incidence of hypersensitivity has also increased. Keefer1 states that the incidence of hypersensitivity following the use of amorphous penicillin in aqueous solution has varied between 2 and 5 per cent. Although there is a belief that hypersensitive reactions are somewhat greater when penicillin in peanut oil and beeswax is used, conclusive evidence is not yet available.2 Beeswax itself has been regarded as nonantigenic,3 but some authorities think that certain persons may become sensitized to it.1 Extensive studies have failed to show that pollen extracts are carried over in . . .