Examination of the conformational dynamics of photoregulated Concanavalin A by time-resolved light scattering
- 1 January 1993
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 23,p. 1753-1755
- https://doi.org/10.1039/c39930001753
Abstract
Spiropyran-modified Concanavalin A (Con-A) displays photoregulated binding towards α-D-mannopyranoside, the photostimulated binding of the substrate originating from a structural perturbation of the protein upon photoisomerization of spiro-Con-A to the zwitterionic Con-A; time-resolved light scattering reveals that the structural change of the protein involves a shrinkage, and the dynamics of the protein shrinkage depend on the loading of Con-A with spiropyran units.Keywords
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