New Efficient Nickel-Catalyzed Cross-Coupling Reaction between Two Csp3Centers

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Abstract
The presence of a remote unsaturation (double bond, carbonyl group, cyano group) in an alkyl halide facilitates its cross-coupling reaction with various diorganozincs in the presence of Ni(acac)2 (7.5−10 mol % in THF/NMP mixtures). These results were used to develop a new general cross-coupling reaction between functionalized diorganozincs and alkyl iodides using m- or p-trifluoromethylstyrene as a reaction promotor and Ni(acac)2 as a catalyst (7.5−10 mol %; −35 °C, 5−10 h) leading to a broad range of polyfunctional cross-coupling products.