Effects of Ethylenediaminetetraacetate and Metal Ions in Intestinal Absorption of Vitamin B12 in Man and Rats
- 1 October 1965
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 120 (1) , 17-20
- https://doi.org/10.3181/00379727-120-30431
Abstract
Summary The effect of metal chelation on intestinal adsorption of B12 was studied in man and in rats. When a physiological dose of B12-Co60 was instilled through an indwelling tube into the duodenum in man, immediately followed by 2 g of EDTA in a dilute solution, absorption was reduced markedly as studied by the Schilling test. Administered shortly after EDTA, Ca++, Mg++, Sr++, but not Fe++, Fe+++, or Zn++ counteracted the inhibition by EDTA. Similar results were obtained with rat intestinal loops. When there was interval between the dosage of B12-Co60 and EDTA, about 3 hours in man and 45 minutes in the case of rat loop were necessary for the absorption to become unaffected by EDTA.This publication has 1 reference indexed in Scilit:
- Intestinal distribution of intrinsic factor and vitamin B12 absorptionAmerican Journal of Physiology-Legacy Content, 1965