Early Malignant Progression of Hereditary Medullary Thyroid Cancer
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Open Access
- 16 October 2003
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 349 (16) , 1517-1525
- https://doi.org/10.1056/nejmoa012915
Abstract
An age-related progression from C-cell hyperplasia to medullary thyroid carcinoma is associated with various germ-line mutations in the rearranged during transfection (RET) proto-oncogene that could be used to identify the optimal time for prophylactic surgery.Keywords
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