Studies on the effect of amoxycillin and ampicillin on Enterobacteriaceae in an experimental model of urinary infection

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Abstract
Fifty-seven isolates of Enterobacteriaceae obtained from hospital and general practice patients were selected to provide a high proportion of organisms resistant to amoxycilin by the filter paper disk technique. Sensitivity test results with amoxycillin were practically identical with those obtained with ampicilin disks. All sensitive organisms and also 10 out of 26 apparently resistant organisms were rapidly killed when incubated with urine from individuals receiving therapeutic doses of amoxycillin or ampidillin. Present methods of testing the sensitivity of these agents may underestimate their effectiveness in treating urinary infections and there appears to be a case for the evaluation of disks with a higher antibiotic content.