Serum disopyramide concentrations and suppression of ventricular premature contractions

Abstract
Serum disopyramide determinations and 24 h Holter monitoring were performed in 20 cardiac subjects with ventricular premature contractions (VPC) after the 1st, 17th and 37th doses of disopyramide, 100 mg (10 subjects; low-dose group) or 200 mg (10 subjects;high-dose group) every 6 h for 10 days to assess the ability of single- or 1st-dose data to predict serum disopyramide concentrations at steady-state (Css), and the relationship between serum disopyramide (Css) and VPC suppression. Control Holter recordings were made for 48 h in each subject. There were strong correlations in both groups between data for the AUC area under the concentration over 0-6 h for the first dose (AUC06) and average (.hivin.Css) and trough (Cmin) steady-rate serum disopyramide concentrations after the 17th and 37th doses, and the 2 combined. .hivin.Css and Cmin were related to AUC06 by the following expressions for both dosage groups: .hivin.Css = 0.22 AUC06 + 0.90 and .cxa.Cmin = 0.20 AUC06 + 0.70. There were good correlations between 6 h serum disopyramide concentration after the 1st dose and .hivin.Css and Cmin. There was strong correlation between overall serum disopyramide (.hivin.Css) and suppression of VPC frequency. The relationship between VPC suppression and overall average trough serum disopyramide Css was weak.

This publication has 3 references indexed in Scilit: