Role of Sodium in Production of Myocardial Necroses by Stress.

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Abstract
Certain Na salts (chloride, acetate, citrate and lactate) are well tolerated even by rats simultaneously treated with 2[alpha]-methyl-9[alpha]-chlorocortisol (Me-Cl-COL) or a severe stressor, such as forced restraint. However, these same salts produce massive and sometimes fatal myocardial necroses in rats exposed to the stress of forced restraint after conditioning With Me-Cl-COL. It appears that during stress the metabolism of certain otherwise innocuous Na salts and/or steroids is so altered that they acquire severe cardiotoxic properties.

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