Catalytic enantioselective reactions. Part 16. Oxazaborolidine-catalyzed asymmetric borane reduction of α-keto acetals
- 1 January 1999
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 15,p. 2095-2100
- https://doi.org/10.1039/a903335a
Abstract
Asymmetric reductions of α-keto acetals using various oxazaborolidines and borane reagents as catalyst and the hydride source, respectively, were compared. The reduction catalyzed by Corey’s CBS reagents with N-phenylamine–borane reagents provided α-hydroxy acetals with very high enantioselectivities for most aromatic analogues.Keywords
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