Potentiometric titrations of vitamin B1 and of thiochrome

Abstract
All authors now agree that vit. B1 reveals a basic group of pK 4.8 but none of pK 3.4. Thiochrome possesses a basic group of pK 5.6; its reaction with alkali is similar to that of vitamin B1 indicating a similarity of structure in having a quaternary N link between the pyrimidine and thiazole nuclei. Thiochrome and its reduction product exhibit at most only a trace of catatorulin activity.

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