Nasal absorption of nifedipine from gel preparations in rats.
- 1 January 1987
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 35 (7) , 3041-3044
- https://doi.org/10.1248/cpb.35.3041
Abstract
Nasal absorption of nifedipine from polyethylene glycol (PEG) 400, aqueous Carbopol gel and Carbopol-PEG gel was investigated with the aim of obtaining high viovailability and prolonged action. Nasal administration of nifedipine in PEG resulted in rapid absorption and high maximum concentration (Cmax). However, the elimination of nifedipine from plasma was very rapid. Nifedipine plasma concentration after nasal administration of nifedipine in aqueous Carbopol gel was very low. On the other hand, Carbopol-PEG gel (containing 50% w/v PEG) showed a relatively high nifedipine concentration and a prolonged action.This publication has 4 references indexed in Scilit:
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- Studies on sustained-release dosage forms. III. Preparation of nifedipine suppositories and bioavailability in rabbits.CHEMICAL & PHARMACEUTICAL BULLETIN, 1985
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