Studies of Hypersensitivity to Fish

Publisher Website
Google Scholar
Abstract
The bis-diazotized-benzidlne (BDB) hemagglutlnation method was used for the detection of antibodies to cod and salmon antigens and was compared with the double diffusion in gel method. With the aid of specific rabbit antisera the method was shown to be specific and sensitive. Haemagglutinating antibodies were present in high titres in the antisera obtained from rabbits immunized with fish. Positive haemagglutination reactions of low titers were obtained with sera from 66.1% of 59 cod hypersensitive children when the erythrocytes were sensitized with cod extract antigen(s). Positive reactions were also found in 27.3% of 55 allergic control children tolerating fish and in 32.2% of 65 non-allergic control children. The BDB hemagglutination reactions probably did not engage the specific reagin in question and in some instances not the allergenic antigen of the fish extract either. The results are discussed.