Influence of cationic superoxide generation enhancing protein (SGEP) on phagocytic and intracellular bactericidal activity of human polymorphonuclear cells
- 1 February 1988
- journal article
- research article
- Published by Springer Nature in Inflammation
- Vol. 12 (1) , 99-106
- https://doi.org/10.1007/bf00915895
Abstract
Cationic fraction III from the lysosomes of normal human peripheral blood polymorphonuclear cells (PMNs) was found to contain superoxide generation enhancing protein (SGEP). Herein, we report on the influence of partially purified SGEP obtained from fraction III (subfractions III-5 and III-6), on various phagocytic functions of human PMNs. SGEP markedly enhanced intracellular bactericidal activity of human peripheral PMNs. The enhancement was time and dose dependent. It also reduced adhesiveness of the PMNs. SGEP did not influence chemotaxis, phagocytosis or phagocytic index. These findings are compatible with our original observation regarding superoxide generation enhancement properties of SGEP.This publication has 23 references indexed in Scilit:
- Modulation of locomotor activity of polymorphonuclear cells by cationic substances and cationic lysosomal fractions from human neutrophilsInflammation, 1985
- Defensins. Natural peptide antibiotics of human neutrophils.Journal of Clinical Investigation, 1985
- Modulation of phagocytosis and intracellular bactericidal activity of polymorphonuclear and mononuclear cells by cationic proteins from human granulocytes: Alternative pathway of phagocytic enhancementInflammation, 1984
- Role of leukocyte factors and cationic polyelectrolytes in phagocytosis of group a streptococci andCandida albicans by neutrophils, macrophages, fibroblasts and epithelial cellsInflammation, 1981
- Modulation of human polymorphonuclear leukocyte chemotaxis by leukocyte extracts, bacterial products, inflammatory exudates, and polyelectrolytesInflammation, 1980
- The influence of natural and synthetic cationic substances on phagocytic activity of human polymorphonuclear cellsExperimental Cell Research, 1978
- The effect of anti-inflammatory agents and inflammation on granulocyte adherenceThe American Journal of Medicine, 1976
- The induction of augmented granulocyte adherence by inflammation. Mediation by a plasma factor.Journal of Clinical Investigation, 1976
- The role of superoxide anion generation in phagocytic bactericidal activity. Studies with normal and chronic granulomatous disease leukocytes.Journal of Clinical Investigation, 1975
- Cationic Proteins of Human Granulocytes: I. Isolation of the Cationic Proteins from the Granules of Leukaemic Myeloid CellsScandinavian Journal of Haematology, 1972