Prevention of platelet adhesion to porous surfaces
- 1 July 1980
- journal article
- research article
- Published by Wiley in Journal of Biomedical Materials Research
- Vol. 14 (4) , 405-415
- https://doi.org/10.1002/jbm.820140407
Abstract
Porous samples of cellulose diacetate/nitrate CAN (millipore filter), polycarbonate PC (nuclepore filter), cellulose diacetate CA, and polydimethyl siloxane SR of various pore sizes were immersed in stirred heparinzied human blood while being perfused with lactated Ringer's solution at variours rates. Control samples were exposed to the blood in the absence of perfusion. The control tests showed that CAN and PC adhered platelets rapidly to plateau levels of 1–5 × 106/cm2 in ∼ 4 min, while CA and SR remained platelet‐free. The critical perfusion rate, v to prevent adhesion of platelets (and all formed elements) to the CAN and PC was ∼0.1 cc/min cm2 at a shear rate of ∼620 sec−1 independent of pore size tested. v increased slightly with stirring rate. A simplified diffusion‐convection model was used to qualitatively account for the effects observed.This publication has 1 reference indexed in Scilit:
- Blood-compatible materials by fluid perfusionJournal of Biomedical Materials Research, 1977