Histamine Production by Transplantable Argyrophilic Gastric Carcinoid of Praomys (Mastomys) natalensis

23 October 1970

journal article
other
Published by American Association for the Advancement of Science (AAAS) in Science

Vol. 170 (3956) , 454-455
https://doi.org/10.1126/science.170.3956.454

Abstract

A transplantable argyrophilic gastric carcinoid of Praomys (Mastomys) natalensis contained appreciable amounts of histamine. Dialyzed, microsome-free supernatant of tumor tissue produced definite amounts of histamine in the presence of L-histidine and pyridoxal phosphate. These findings may relate to hypersecretion of gastric acid and formation of multiple ulcers in the stomach and duodenum of Mastomys bearing carcinoids.

Keywords

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