Haemorrhage produces depressions in alloantigen-specific immune responses in the mouse through activation of suppressor T cells

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Abstract
SUMMARY: The development of cell-mediated and humoral immune responses in BALB/c mice (H-2d) directed toward El4 cells (H-2b) was suppressed (cell-mediated cytotoxicity, 40–50% of control; antibody titres 127±17 versus 287±17 in controls) following haemorrhage of 30% total blood volume. This haemorrhage-induced depression of immune response can be transferred to normal recipients with T cells (3 × 107) from haemorrhaged syngeneic donors. Flow microfluorimetry (FMF) analysis showed no shift in CD8:CD4 ratios following haemorrhage. These results suggest that haemorrhage suppresses immune response through activation of suppressor T cells.