TC-99M PYRIDOXYLIDENE GLUTAMATE IN JAUNDICED PATIENTS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 19  (1) , 24-27
Abstract
Ninety patients, 85 of them jaundiced, were examined after injection of 99mTc pyridoxylidene glutamate, a substance rapidly concentrated by normal hepatocytes and excreted into the biliary tract. It appears in the gallbladder after 10-15 min and in the gastrointestinal tract at 30 min. On the basis of time of appearance in the intestine, 4 groups of patients were recognized: 17 patients with a normal pattern, with visualization of the gut at 30 min; 19 patients with a slight delay in passage, with appearance in the gut between 30-180 min; 29 patients showing very slow excretion visualized only at 24 h (21 of these had parenchymatous disease of the liver, 3 choledocholithiasis and 5 had malignant disease causing partial obstruction); and 25 patients with no visualization of the intestine (8 of them were cases of medical jaundice and 17 were surgical cases). If lack of intestinal activity was considered as indicating surgical jaundice, the accuracy of this study was only 72.4%.

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