Time-of-Flight Flow Imaging of Two-Component Flow inside a Microfluidic Chip
- 5 January 2007
- journal article
- research article
- Published by American Physical Society (APS) in Physical Review Letters
- Vol. 98 (1) , 017601
- https://doi.org/10.1103/physrevlett.98.017601
Abstract
Here we report on using NMR imaging and spectroscopy in conjunction with time-of-flight tracking to noninvasively tag and monitor nuclear spins as they flow through the channels of a microfluidic chip. Any species with resolvable chemical-shift signatures can be separately monitored in a single experiment, irrespective of the optical properties of the fluids, thereby eliminating the need for foreign tracers. This is demonstrated on a chip with a mixing geometry in which two fluids converge from separate channels, and is generally applicable to any microfluidic device through which fluid flows within the nuclear spin-lattice relaxation time.Keywords
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