CHANGES IN THE METABOLISM OF S35-LABELED SULFATE ASSOCIATED WITH RENAL CALCIFICATION

Abstract
Renal calcification was produced in 50 laboratory mice of mixed sexes by the administration of parathyroid extract or 10% calcium gluconate. 10 µc. of Na2S35O4 was injected into each mouse 24 hours prior to sacrifice. The renal calcification resulting from the administration of PTE was accompanied by an increase in the amount of bound S36. This increase was proportionate to the degree of calcification. No change in sulfate binding accompanied the calcification produced by calcium gluconate.

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