Chemistry of the mycalamides, antiviral and antitumour compounds from a marine sponge. Part 5. Acid-catalysed hydrolysis and acetal exchange, double bond additions and oxidation reactions
- 1 January 1995
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 10,p. 1233-1242
- https://doi.org/10.1039/p19950001233
Abstract
The acid-catalysed degradations of the potent antitumour and antiviral sponge metabolite mycalamide A and a triacetyl derivative have been examined. Acetal exchange reactions, catalytic hydrogenation, epoxidation and oxidation reactions have also been performed on mycalamides A and B. The major products derived from these reactions were characterised and tested for in vitro P388 anti-leukaemia activity and structure–activity relationships were deduced from these results.Keywords
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