Intranuclear Inclusions in Rattus (Mastomys) Natalensis Infected With Rat Virus

Publisher Website
Google Scholar
Abstract
Newborn mastomys inoculated with rat virus (RV), an agent originally isolated from tumor-bearing rats, develop an acute fatal disease characterized histopathologically by Feulgen-positive intranuclear inclusions in reticuloendothelial cells in the liver, heart, lungs, kidneys, spleen, and gastrointestinal tract. The inclusions resemble those seen in cells infected with polyoma virus in vitro. Although polyoma virus and RV have a number of common biological properties, including the ability of both agents to infect mastomys with involvement of Kupffer cells in the liver, no evidence of proliferative or oncogenic activity has been observed in mastomys inoculated with RV.