Influence of Histamine Liberator Substance 48/80 on Basophil Leucocytes of Rabbit Blood.

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Abstract
In 28 rabbits, compound 48/80 in saline solution, when injected intravenously (1 mg/kg), induced a decrease in circulating basophil counts, maximally after 6 hours. Compared to control counts obtained from the same animals following saline injection on a previous day, a significant difference at the 0.1 % level was found. As with tissue mast cells, compound 48/80 might degranulate circulating basophils hence releasing their histamine-containing metachromatic granules. Another possibility is that in response to tissue edema induced by histamine liberation due to compound 48/80, the circulating basophils might migrate to the tissues. Rabbit tissues contain comparatively few mast cells; so the much more numerous basophil leucocytes may be called upon to release their mucopolysaccharide content, binding extracellular water, and converting it to a ground-substance-like hydrated gel.

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