STUDIES ON BLOOD-BRAIN BARRIER WITH RADIOACTIVE PHOSPHORUS
- 1 November 1952
- journal article
- other
- Published by American Medical Association (AMA) in A.M.A. Archives of Neurology & Psychiatry
- Vol. 68 (5) , 629-640
- https://doi.org/10.1001/archneurpsyc.1952.02320230055006
Abstract
GENERAL principles regarding the blood-brain barrier of the animal brain measured with P32have been reported in an earlier paper.1It was found that P32can be used, more accurately than any other agent, to determine the permeability of the barrier under physiologic conditions. In these earlier experiments, after intravenous injection of the tracer, there was found in the pituitary gland of the rabbit a higher P32content than in the central nervous system. This phenomenon was explained by the fact that the hypophysis lacks any particular barrier and incorporates phosphates as other organs do, an explanation supported by vital-dye studies.2No definite difference in behavior could be demonstrated, however, between the hypothalamus and the rest of the brain, nor could a distinction be made in the various lobes of the pituitary gland itself. It did not appear possible to carry out such determinations onKeywords
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