Cerebrovascular Disease

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Abstract
A study was made in 100 consecutive cases of intracerebral arteries measuring 150 to 500 [mu]. The chief degenerative change is limited to the adventitia which undergoes proliferation and ultimately replaces the entire vessel wall, causing a fibrotic vessel. Intimal changes or fatty deposits al- most never occur. Vascular fibrosis first appears in the third decade of life but is not severe until the fifth decade. Even in elderly subjects, over 50% of the patients will show little or no change within these smaller arteries. No correlation is found between the changes in these arteries and atherosclerosis in the larger arteries along the base of the brain. In 50% of cases showing severe fibrosis of the smaller arteries, little or no atherosclerosis occurred in the larger vessels. Severe fibrosis of these smaller arteries was twice as frequent in patients with hypertension or cardiac enlargement. Other somatic diseases were apparently not etiologically concerned in this process.

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