Allergic contact dermatitis caused by naturally occurring quinones
- 1 June 1991
- journal article
- review article
- Published by Springer Nature in International Journal of Clinical Pharmacy
- Vol. 13 (3) , 119-122
- https://doi.org/10.1007/bf01981527
Abstract
Quinones play a major role in allergic contact dermatitis caused by plants. The principal allergens are benzoquinones or naphthoquinones but also compounds, such as catechols and other phenolic or flavonoid compounds, which are bioconverted intoortho-quinones orpara-quinones. The high electrophilic reactivity of these compounds toward nucleophilic residues of proteins associated with lipophilic properties may explain that they are strong sensitizers. The more important allergens are reported and their structure-activity relationship is discussed.Keywords
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