Dipyridamole, an Inhibitor of Mengovirus Replication in FL and L Cells

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Abstract
Dipyridamole showed an antiviral activity against mengovirus in FL cells using the agar diffusion plaque inhibition test, plaque reduction test, tube titra-tion test, and virus yield test after one replication cycle. With the last two tests mentioned aboye the inhibitory action was also confirmed in L cells. In consequence of the known transport inhibition of uridine into the cell in presence of dipyridamole only a very small incorporation of 3H-uridine into acid-insoluble material could be demonstrated. Applying the method of prelabelling of FL cells at 16°C for 1 h with subsequent addition of dipyridamole the drug failed to show an effect on cellular RNA synthesis per se in uninfected cells whereas the viral RNA synthesis in mengo-virus-infected L cells was completely depressed.

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