THE INFLUENCE OF HLA-A, B, AND DR MATCHING ON GRAFT SURVIVAL INPARIMARY CADAVERIC RENAL TRANSPLANTATION IN BELFAST

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Abstract
HLA-DR matching has been shown in a retrospective study of 72 renal transplant patients to significantly enhance graft survival at 12 mo. HLA-A and -B antigen matching matching also increased the graft survival rate significantly. Analysis of combined HLA-A, -B and -DR matching suggested an improvement in graft survival rate with better matching, but this did not attain statistical significance. Thus, current policy is to ensure that all recipients receive a kidney with a maximum of 1 HLA-DR incompatibility and a minimum of 2 HLA-A and -B antigens shared.

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