THE METABOLISM OF SOME CHEMICAL DEGRADATION PRODUCTS OF ESTROGENS: WESTERFELD’S LACTONE, BIS-DEHYDRO-DOISYNOLIC ACID, ESTROLOLACTONE ANDβ-ESTRADIOL

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Abstract
[alpha]-Estradiol and some estrogen degradation products were injected subcutaneously. It was observed that they could be arranged in the following order of decreasing estrogenic potency: 3-methyl ether of bis-de-hydro-doisynolic acid > sodium bis-dehydro-doisynolate> a-estradiol > Westerfeld''s lactone acetate > [beta]-estradiol > estrololactone acetate. When a-estradiol was injected intra-splenically instead of subcut., 43 times as much was required to produce vaginal estrus in one half of the animals. In-trasplenic injns. of [beta]-estradiol, Westerfeld''s lactone acetate and estrololactone acetate with 12, 17 and 3 times the subcut. 50% estrus dose, respectively, failed to produce estrus in 50% of the animals. Intrasplenic injns. of the 3-methyl ether of bis-dehydro-doisynolic acid and Na bis-dehydro-doisyno- late required only 1/2 as much to produce vaginal estrus in 50% of the animals as when the estrogen was administered subcut. These results are interpreted as indicating that the liver inactivates [alpha]- and [beta]-estradiol, Westerfeld''s lactone acetate and estrololactone acetate but enhances the estrogenic potency (activates) of the 3-methyl ether of bis-dehydro-doisynolic acid and Na bis-dehydrodoisynolate.

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