Abyssomicins, Inhibitors of the para-Aminobenzoic Acid Pathway Produced by the Marine Verrucosispora Strain AB-18-032
Top Cited Papers
- 1 January 2004
- journal article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 57 (4) , 271-279
- https://doi.org/10.7164/antibiotics.57.271
Abstract
A screening method was established to detect inhibitors of the biosynthetic pathways of aromatic amino acids and para-aminobenzoic acid, the precursor of folic acid, using an agar plate diffusion assay modified as an antagonism test. By this screening method, a family of three novel polycyclic polyketides named as abyssomicins was isolated from a marine strain of Verrucosispora. The main component abyssomicin C inhibits the pathway between chorismate and para-aminobenzoic acid and is strongly active against Gram-positive bacteria, including multi-resistant clinical isolates of Staphylococcus aureus.Keywords
This publication has 0 references indexed in Scilit: