Peptide synthesis. Part 5. Solid-phase synthesis of [15-leucine]little gastrin
- 1 January 1983
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- p. 1161-1167
- https://doi.org/10.1039/p19830001161
Abstract
A procedure is described for the solid-phase synthesis of gastrin peptides exemplified by [15-leucine]little gastrin. The method makes use of a polar polyamide resin support and stepwise addition of fluorenylmethoxycarbonylamino-acid derivatives. Treatment with acidic reagents is minimised, obviating the need for side-chain protection of tryptophan and eliminating acid-catalysed side reactions at the multiple glutamyl residues. Formation of the terminal pyroglutamyl residue was achieved through a glutaminyl intermediate.Keywords
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