ORGANIC CHANGES IN PHENYTOIN-INTOXICATED PIGS

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Abstract
Two of 3 pigs weighing approximately 20 kg received increasing doses of phenytoin perorally until signs of intoxication developed in the course of about 2 months. The condition was maintained for almost 1 month. The signs of intoxication developed at serum concentrations of phenytoin of the same order as those in intoxicated humans. The high rate of elimination in the pigs necessitated a higher ingestion per kg body weight. At autopsy, moderately pronounced cerebellar damage was found. The liver and kidneys presented lesions which may be reversible.