Inhibition of Renal Tubular Responsiveness to Antidiuretic Hormone By Pyrogens.
- 1 March 1955
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 88 (3) , 451-454
- https://doi.org/10.3181/00379727-88-21616
Abstract
In dogs a water diuresis was established and then inhibited by intravenous Pitressin. The Pitressin infusion was continued and a single large intravenous pyrogen dose then given. After a delay period a water diuresis developed. During pyrogen diuresis the urine was markedly hyposmolar to plasma indicating antidiuretic hormone (ADH) inhibition. If a pyrogen diuresis is established first, it cannot be inhibited by large doses of Pitressin. These experiments indicate an alteration of renal tubular response to ADH induced by pyrogens.Keywords
This publication has 1 reference indexed in Scilit:
- REACTION OF TISSUES TO ADMINISTRATION OF A PYROGENIC PREPARATION FROM A PSEUDOMONAS SPECIESThe Lancet Healthy Longevity, 1950