Natural Killer (NK) Cell Activity of Peripheral Blood Lymphocytes from Patients with Bechterew's Syndrome (Ankylosing Spondylitis)

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Abstract
Sixteen patients with Bechterew's syndrome (ankylosing spondylitis, AS) were investigated. All except one of the patients were HLA B27-positive. Peripheral blood lymphocytes from the patients were examined for spontaneous cytotoxicity against 51Cr-labelled K562 target cells. The cytotoxicity index of the non-T lymphocytes was negatively correlated with the serum CRP concentration (Pearson's r=0.613, p>0.01 g/l) compared with normal controls, (14.6±2.8 g/l versus 20.4±2.4 g/l mean ±SE; ppp<0.05 respectively) Interferon caused normal augmentation in the NK cell activity in AS patients, and no correlation was found between serum gamma interferon titres and the NK cell activity.