Homocytotropic Antibody Response in the Rat Infected with the Nematode, Nippostrongylus Brasiliensis

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Abstract
Summary: In contrast to rats immunized with standard antigens and adjuvants which produce homocytotropic antibody in low titer only during the primary response, rats infected with N. brasiliensis larvae synthesized H.A. for prolonged periods and manifested a secondary response on reinfection. Washed peritoneal cells obtained from actively infected rats or normal peritoneal cells passively sensitized in vitro with serum from infected rats released histamine upon contact with worm antigens. The possible role of H.A. and H.A.-sensitized mast cells in host immunity to N. brasiliensis infection was discussed.

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