Polyamines Inhibit the Protein Kinase 380—Catalyzed Phosphorylation of Eukaryotic Initiation Factor 2α
- 22 January 1982
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 215 (4531) , 415-416
- https://doi.org/10.1126/science.7058326
Abstract
Polyamines putrescine, spermidine, and spermine specifically inhibit the PK 380--catalyzed phosphorylation of eukaryotic initiation factor 2 alpha (eIF-2 alpha). Since te PK 380--dependent phosphorylation of eIF-2 alpha inhibits the initiation or protein synthesis, the possibility exists that the polyamines enhance protein synthesis by inhibiting the phosphorylation of eIF-2 alpha by PK 380.This publication has 31 references indexed in Scilit:
- Stimulation of polypeptide synthesis by spermidine at the level of initiation in rabbit reticulocyte and wheat germ cell-free systemsBiochemical and Biophysical Research Communications, 1980
- Partial purification and characterization of a novel bovine adrenocortical protein kinase that phosphorylates endogenous 120,000 dalton peptideBiochemical and Biophysical Research Communications, 1980
- Phosphorylation of initiation factor eIF-2 and the control of reticulocyte protein synthesisCell, 1977
- The Role of Polyamines in Cell-Free Protein Synthesis in the Wheat-Germ SystemEuropean Journal of Biochemistry, 1977
- Evidence that griseofulvin binds to a microtubule associated proteinFEBS Letters, 1977
- Interferon-mediated protein kinase and low-molecular-weight inhibitor of protein synthesisNature, 1976
- 1,4-Diaminobutane (Putrescine), Spermidine, and SpermineAnnual Review of Biochemistry, 1976
- A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingAnalytical Biochemistry, 1976
- Effect of Polyamines on Polyphenylalanine Synthesis by Escherichia coli and Rat-Liver RibosomesEuropean Journal of Biochemistry, 1974
- Hormonal Regulation of Spermidine Formation during Spermatogenesis in the Rat*Endocrinology, 1973