Indomethacin in Rheumatic Diseases

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Abstract
The therapeutic effectiveness of the drug was shown by a double-blind controlled trial on 22 patients, and a further 33 patients mainly suffering from rheumatoid arthritis were treated with this drug over periods extending from 4 to 40 weeks. Though the drug is effective in controlling pain and stiffness, there was a fairly high incidence of headache and giddiness; this was partially overcome by starting with a low dosage which was then gradually increased. In addition, the drug may cause gastrointestinal bleeding in some patients, though less frequently than aspirin; 2 patients had major gastrointestinal complications while being treated with indomethacin.