Comparative Effects of Cyclosporine A and FK-506 on Endothelin Secretion by a Cultured Renal Cell Line, LLC-PK1

1 January 1991

journal article
research article
Published by Wolters Kluwer Health in Journal of Cardiovascular Pharmacology

Vol. 17, S172-173
https://doi.org/10.1097/00005344-199100177-00048

Abstract

Cyclosporine A (CSA) stimulated endothelin secretion by a cultured renal epithelial cell line, LLC-PK1. A less nephrotoxic immunosuppressant (FK-506) did not affect endothelin secretion. Putative endothelin converting enzyme inhibitors or specific receptor antagonists may therefore prevent CSA nephrotoxicity.

Keywords

CYCLOSPORINE
IMMUNOSUPPRESSANT
ANTAGONISTS
EPITHELIAL
STIMULATED
CONVERTING
PK1
ENDOTHELIN SECRETION

This publication has 0 references indexed in Scilit: