Multiple intravenous dose pharmacokinetic study of carnmonam in healthy subjects

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Abstract
Steady-state pharmacokinetics of carumonam were investigated in twelve healthy adult male volunteers after 20 min intravenous infusions of three consecutive carumonam dosage regimens: 1 g every 8 h (3 g/day) from 0–72 h, 2 g every 8 h (6 g/day) from 88–120 h and 2 g every 6 h (8 g/day) from 132–216 h. Serial plasma samples were collected after the first dose of the first regimen and the last dose of all three regimens and were analysed for carumonam by a specific HPLC method. The overall mean maximal plasma concentrations were 108 and 211 mg/l at the end of infusion of 1 and 2 g, respectively. The steady-state pharmacokinetic parameters and plasma concentration-time profiles of carumonam when adjusted for dose were similar for the three regimens. The overall terminal elimination half-life was 1·4 h (range 1·1–1·8 h), the apparent volume of distribution at steady state reached 11·5 l (range 8·7–15·5 l) and the total systemic clearance amounted to 118 ml/min (range 83–158 ml/min). Considering the frequency of dosing relative to the elimination half-life, accumulation of the drug in plasma was not expected and none was found from any of the three regimens. Carumonam was well tolerated up to 8 g/day and exhibited dose-independent pharmacokinetics which were not altered upon multiple dosing.