Current management of locally advanced pancreatic cancer
- 1 August 2005
- journal article
- review article
- Published by Springer Nature in Nature Clinical Practice Gastroenterology & Hepatology
- Vol. 2 (8) , 356-364
- https://doi.org/10.1038/ncpgasthep0240
Abstract
Almost 30% of patients with pancreatic cancer present with large, locally advanced tumors in the absence of distant metastases. Because surgical resection is frequently contraindicated by vascular invasion, locally advanced pancreatic cancer has a dismal prognosis with a 6-10-month median survival. Recent advances in the multimodality treatment of other gastrointestinal malignancies have not altered the management of patients with locally advanced pancreatic cancer, a clinical dilemma reflected by the number of nonrandomized trials and anecdotal reports addressing this difficult disease. Our review summarizes the current status of aggressive surgical resection and neoadjuvant chemoradiation for locally advanced pancreatic cancer and suggests a treatment algorithm for patients with this disease based upon published clinical evidence.Keywords
This publication has 53 references indexed in Scilit:
- Diagnostic laparoscopy improves staging of pancreatic cancer deemed locally unresectable by Computed TomographySurgical Endoscopy, 2005
- Pancreaticoduodenectomy with vascular resection: margin status and survival durationJournal of Gastrointestinal Surgery, 2004
- Is there a role for staging laparoscopy in patients with locally advanced, unresectable pancreatic adenocarcinoma?Journal of Gastrointestinal Surgery, 2004
- The evolution of adjuvant and neoadjuvant chemotherapy and radiation for advanced pancreatic cancer: from 5-fluorouracil to GTXSurgical Oncology Clinics of North America, 2004
- Extended Radical Resection Versus Standard Resection for Pancreatic CancerPancreas, 2004
- A Randomized Trial of Chemoradiotherapy and Chemotherapy after Resection of Pancreatic CancerNew England Journal of Medicine, 2004
- Comparison of Gemcitabine Versus the Matrix Metalloproteinase Inhibitor BAY 12-9566 in Patients With Advanced or Metastatic Adenocarcinoma of the Pancreas: A Phase III Trial of the National Cancer Institute of Canada Clinical Trials GroupJournal of Clinical Oncology, 2003
- Phase II study of gemcitabine combined with radiation therapy in patients with localized, unresectable pancreatic cancerJournal of Surgical Oncology, 2002
- Surgical strategy for carcinoma of the pancreas head area based on clinicopathologic analysis of nodal involvement and plexus invasionSurgery, 1995
- Surgical Palliation for Pancreatic CancerAnnals of Surgery, 1990